Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Satyajit Mohite; Salvina M. de Campos-Carli; Natalia P. Rocha; Shiva Sharma; Aline S. Miranda; Izabela G. Barbosa; Joao V. Salgado; Ana Cristina Simoes-e-Silva; Antonio L. Teixeira

doi:10.1016/j.schres.2018.06.023

Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Satyajit Mohite
, Salvina M. de Campos-Carli
, Natalia P. Rocha
, Shiva Sharma
, Aline S. Miranda
, Izabela G. Barbosa
, Joao V. Salgado
, Ana Cristina Simoes-e-Silva
, Antonio L. Teixeira

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

Original language	English (US)
Pages (from-to)	50-54
Number of pages	5
Journal	Schizophrenia research
Volume	202
DOIs	https://doi.org/10.1016/j.schres.2018.06.023
State	Published - Dec 2018
Externally published	Yes

Keywords

Angiotensin
Angiotensin-converting enzyme
Cognition
Renin-angiotensin system (RAS)
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2018.06.023

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title = "Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia",

abstract = "This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.",

keywords = "Angiotensin, Angiotensin-converting enzyme, Cognition, Renin-angiotensin system (RAS), Schizophrenia",

author = "Satyajit Mohite and \{de Campos-Carli\}, \{Salvina M.\} and Rocha, \{Natalia P.\} and Shiva Sharma and Miranda, \{Aline S.\} and Barbosa, \{Izabela G.\} and Salgado, \{Joao V.\} and Simoes-e-Silva, \{Ana Cristina\} and Teixeira, \{Antonio L.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = dec,

doi = "10.1016/j.schres.2018.06.023",

language = "English (US)",

volume = "202",

pages = "50--54",

journal = "Schizophrenia research",

issn = "0920-9964",

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AU - Mohite, Satyajit

AU - de Campos-Carli, Salvina M.

AU - Rocha, Natalia P.

AU - Sharma, Shiva

AU - Miranda, Aline S.

AU - Barbosa, Izabela G.

AU - Salgado, Joao V.

AU - Simoes-e-Silva, Ana Cristina

AU - Teixeira, Antonio L.

PY - 2018/12

Y1 - 2018/12

N2 - This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

AB - This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

KW - Angiotensin

KW - Angiotensin-converting enzyme

KW - Cognition

KW - Renin-angiotensin system (RAS)

KW - Schizophrenia

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UR - https://www.scopus.com/pages/publications/85048834331#tab=citedBy

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DO - 10.1016/j.schres.2018.06.023

M3 - Article

C2 - 29925475

AN - SCOPUS:85048834331

SN - 0920-9964

VL - 202

SP - 50

EP - 54

JO - Schizophrenia research

JF - Schizophrenia research

ER -

Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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