Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Satyajit Mohite, Salvina M. de Campos-Carli, Natalia P. Rocha, Shiva Sharma, Aline S. Miranda, Izabela G. Barbosa, Joao V. Salgado, Ana Cristina Simoes-e-Silva, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalSchizophrenia research
StatePublished - Dec 2018
Externally publishedYes


  • Angiotensin
  • Angiotensin-converting enzyme
  • Cognition
  • Renin-angiotensin system (RAS)
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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