Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage

Gregory B. York; Jeffrey S. Eggers; David L. Smith; Donald H. Jenkins; Jeffrey D. McNeil; Deborah Mueller; John D. Josephs; Jeffrey D. Kerby

doi:10.1097/01.TA.0000092681.17874.6F

Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage

Gregory B. York
, Jeffrey S. Eggers
, David L. Smith
, Donald H. Jenkins
, Jeffrey D. McNeil
, Deborah Mueller
, John D. Josephs
, Jeffrey D. Kerby

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Background: We have shown in a previous work that HBOC-201 is able to reverse anaerobic metabolism at low volumes in a porcine model of controlled hemorrhage. On the basis of these results, we hypothesize that low-volume resuscitation with HBOC-201 in a porcine model of controlled hemorrhage provides adequate tissue oxygenation to limit end-organ damage and allow for survival of the animal.

Original language	English (US)
Pages (from-to)	873-885
Number of pages	13
Journal	Journal of Trauma
Volume	55
Issue number	5
DOIs	https://doi.org/10.1097/01.TA.0000092681.17874.6F
State	Published - Nov 2003
Externally published	Yes

Keywords

Blood substitute
Hemoglobin-based oxygen-carrying (HBOC) solution
Hemorrhage
Porcine
Resuscitation

ASJC Scopus subject areas

Surgery
Critical Care and Intensive Care Medicine

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10.1097/01.TA.0000092681.17874.6F

Cite this

York, G. B., Eggers, J. S., Smith, D. L., Jenkins, D. H., McNeil, J. D., Mueller, D., Josephs, J. D., & Kerby, J. D. (2003). Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage. Journal of Trauma, 55(5), 873-885. https://doi.org/10.1097/01.TA.0000092681.17874.6F

Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage. / York, Gregory B.; Eggers, Jeffrey S.; Smith, David L. et al.
In: Journal of Trauma, Vol. 55, No. 5, 11.2003, p. 873-885.

Research output: Contribution to journal › Article › peer-review

York, GB, Eggers, JS, Smith, DL, Jenkins, DH, McNeil, JD, Mueller, D, Josephs, JD & Kerby, JD 2003, 'Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage', Journal of Trauma, vol. 55, no. 5, pp. 873-885. https://doi.org/10.1097/01.TA.0000092681.17874.6F

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abstract = "Background: We have shown in a previous work that HBOC-201 is able to reverse anaerobic metabolism at low volumes in a porcine model of controlled hemorrhage. On the basis of these results, we hypothesize that low-volume resuscitation with HBOC-201 in a porcine model of controlled hemorrhage provides adequate tissue oxygenation to limit end-organ damage and allow for survival of the animal.",

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AU - Jenkins, Donald H.

AU - McNeil, Jeffrey D.

AU - Mueller, Deborah

AU - Josephs, John D.

AU - Kerby, Jeffrey D.

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Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage

Abstract

Keywords

ASJC Scopus subject areas

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