Background: We have shown in a previous work that HBOC-201 is able to reverse anaerobic metabolism at low volumes in a porcine model of controlled hemorrhage. On the basis of these results, we hypothesize that low-volume resuscitation with HBOC-201 in a porcine model of controlled hemorrhage provides adequate tissue oxygenation to limit end-organ damage and allow for survival of the animal.
- Blood substitute
- Hemoglobin-based oxygen-carrying (HBOC) solution
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine