Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage

Gregory B. York, Jeffrey S. Eggers, David L. Smith, Donald H. Jenkins, Jeffrey D. McNeil, Deborah Mueller, John D. Josephs, Jeffrey D. Kerby

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background: We have shown in a previous work that HBOC-201 is able to reverse anaerobic metabolism at low volumes in a porcine model of controlled hemorrhage. On the basis of these results, we hypothesize that low-volume resuscitation with HBOC-201 in a porcine model of controlled hemorrhage provides adequate tissue oxygenation to limit end-organ damage and allow for survival of the animal.

Original languageEnglish (US)
Pages (from-to)873-885
Number of pages13
JournalJournal of Trauma
Volume55
Issue number5
DOIs
StatePublished - Nov 2003

Keywords

  • Blood substitute
  • Hemoglobin-based oxygen-carrying (HBOC) solution
  • Hemorrhage
  • Porcine
  • Resuscitation

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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