LOW LEVEL INCORPORATION OF TRITIATED THYMIDINE INTO THE NUCLEAR DNA OF PURKINJE NEURONS OF ADULT MICE

I. L. Cameron, Mary R.H. Pool, T. R. Hoage

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Adult mice were pulse labeled with tritiated thymidine [3H]TdR and killed 9 hr later. A low level incorporation of [3H]TdR into the nuclear DNA of Purkinje neurons was found in autoradiographs. Enzymatic digestions with DNase and with RNase in combination with autoradiographic grain counts indicate that a portion of nuclear DNA is not stable in the Purkinje nucleus. These results are discussed in light of reports of the stable nature of DNA in Purkinje neurons of adult mice.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalCell Proliferation
Volume12
Issue number4
DOIs
StatePublished - Jul 1979
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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