Abstract
BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 324-328 |
| Number of pages | 5 |
| Journal | Journal of Reproductive Medicine for the Obstetrician and Gynecologist |
| Volume | 49 |
| Issue number | 4 |
| State | Published - Apr 2004 |
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Keywords
- Carcinoma, squamous cell
- Endometrial stromal sarcoma
- Intrauterine devices
- Uterine cancer
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine
Cite this
Low Grade Uterine Stromal Sarcoma and Squamous Cell Carcinoma Associated with an IUD : A Report of 2 Cases. / Valente, Philip T; Ahmad, Mohammad M.
In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 49, No. 4, 04.2004, p. 324-328.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low Grade Uterine Stromal Sarcoma and Squamous Cell Carcinoma Associated with an IUD
T2 - A Report of 2 Cases
AU - Valente, Philip T
AU - Ahmad, Mohammad M.
PY - 2004/4
Y1 - 2004/4
N2 - BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.
AB - BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.
KW - Carcinoma, squamous cell
KW - Endometrial stromal sarcoma
KW - Intrauterine devices
KW - Uterine cancer
UR - http://www.scopus.com/inward/record.url?scp=1942470393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1942470393&partnerID=8YFLogxK
M3 - Article
C2 - 15134161
AN - SCOPUS:1942470393
VL - 49
SP - 324
EP - 328
JO - The Journal of reproductive medicine
JF - The Journal of reproductive medicine
SN - 0024-7758
IS - 4
ER -