Low Grade Uterine Stromal Sarcoma and Squamous Cell Carcinoma Associated with an IUD: A Report of 2 Cases

Philip T Valente, Mohammad M. Ahmad

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume49
Issue number4
StatePublished - Apr 2004

Fingerprint

Intrauterine Devices
Stromal Cells
Sarcoma
Squamous Cell Carcinoma
Pyometra
Uterine Neoplasms
Fallopian Tubes
Uterus
In Situ Hybridization
Neoplasms
DNA

Keywords

  • Carcinoma, squamous cell
  • Endometrial stromal sarcoma
  • Intrauterine devices
  • Uterine cancer

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

@article{5ffacf156a5741ee9880e5b65fe05b38,
title = "Low Grade Uterine Stromal Sarcoma and Squamous Cell Carcinoma Associated with an IUD: A Report of 2 Cases",
abstract = "BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.",
keywords = "Carcinoma, squamous cell, Endometrial stromal sarcoma, Intrauterine devices, Uterine cancer",
author = "Valente, {Philip T} and Ahmad, {Mohammad M.}",
year = "2004",
month = "4",
language = "English (US)",
volume = "49",
pages = "324--328",
journal = "The Journal of reproductive medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "4",

}

TY - JOUR

T1 - Low Grade Uterine Stromal Sarcoma and Squamous Cell Carcinoma Associated with an IUD

T2 - A Report of 2 Cases

AU - Valente, Philip T

AU - Ahmad, Mohammad M.

PY - 2004/4

Y1 - 2004/4

N2 - BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.

AB - BACKGROUND: Although intrauterine device (IUD) usage has not been linked to uterine cancer and has even been considered protective against neoplasia, sporadic cases of IUD-associated uterine malignancies have been reported. CASES: One cystic low grade stromal sarcoma of the uterus occurred in a 7-year IUD user, and 1 invasive endometrial squamous cell carcinoma following 25 years of IUD retention occurred in another. The latter case was notable for extensive in situ squamous cell carcinoma involving the entire uterine cavity and extending to the ectocervix and into both fallopian tubes. In situ hybridization for high-risk HPV DNA was negative. These findings raise the possibility of a non-HPV-related pathwayfor the squamous cell carcinoma case due possibly to prolonged chronic irritation and pyometra. CONCLUSION: The association of low grade stromal sarcoma with the IUD in the first case is extremely rare and most likely coincidental. The squamous carcinoma case, however, may have arisen via a non-HPV-related pathway, possibly related to IUD-induced chronic irritation and pyometra.

KW - Carcinoma, squamous cell

KW - Endometrial stromal sarcoma

KW - Intrauterine devices

KW - Uterine cancer

UR - http://www.scopus.com/inward/record.url?scp=1942470393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942470393&partnerID=8YFLogxK

M3 - Article

C2 - 15134161

AN - SCOPUS:1942470393

VL - 49

SP - 324

EP - 328

JO - The Journal of reproductive medicine

JF - The Journal of reproductive medicine

SN - 0024-7758

IS - 4

ER -