Low-dose versus high-dose oxytocin augmentation of labor — A randomized trial

Elly M.J. Xenakis, Oded Langer, Jeanna M. Piper, Deborah Conway, Michael D. Berkus

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


OBJECTIVE: Our purpose was to compare the efficacy and safety of low-dose versus high-dose oxytocin regimens in the augmentation of labor. STUDY DESIGN: Three hundred ten term pregnancies requiring augmentation of labor underwent randomization to receive either a low-dose or high-dose oxytocin augmentation regimen. Maternal demographics, labor-delivery data, and neonatal outcome were compared. RESULTS: The hgih-dose oxytocin group had a significant lower cesarean section rate, regarless of parity (10.4% vs 25.7%. p < 0.001), with no differences in maternal complications and neonatal outcomes. The time needed to correct the labor abnormality as also significantly decreased (1.24 ± 1.4 hours vs 3.12 ± 1.6 hours, p < 0.001) in the high-dose group. CONCLUSIONS: The use of a high-dose oxytocin regimen benefits both nulliparous and multiparous women requiring labor augmentation by significantly lowering both the time necessary to correct the labor normality and the need for cesarean section.

Original languageEnglish (US)
Pages (from-to)1874-1878
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - 1995


  • Labor abnormalities
  • augmentation
  • oxytoxin

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Low-dose versus high-dose oxytocin augmentation of labor — A randomized trial'. Together they form a unique fingerprint.

Cite this