Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

J. P. Kinsella, S. R. Neish, E. Shaffer, S. H. Abman

Research output: Contribution to journalArticlepeer-review

574 Scopus citations

Abstract

We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.

Original languageEnglish (US)
Pages (from-to)819-820
Number of pages2
JournalThe Lancet
Volume340
Issue number8823
DOIs
StatePublished - Oct 3 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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