Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

J. P. Kinsella, Steven Neish, E. Shaffer, S. H. Abman

Research output: Contribution to journal › Article

566 Citations (Scopus)

Abstract

We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.

Original languageEnglish (US)
Pages (from-to)819-820
Number of pages2
JournalThe Lancet
Volume340
Issue number8823
DOIs
StatePublished - Oct 3 1992
Externally publishedYes

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Persistent Fetal Circulation Syndrome
Nitric Oxide
Extracorporeal Membrane Oxygenation
Pulmonary Hypertension
Newborn Infant
Blood Pressure
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. / Kinsella, J. P.; Neish, Steven; Shaffer, E.; Abman, S. H.

In: The Lancet, Vol. 340, No. 8823, 03.10.1992, p. 819-820.

Research output: Contribution to journal › Article

Kinsella, JP, Neish, S, Shaffer, E & Abman, SH 1992, 'Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn', The Lancet, vol. 340, no. 8823, pp. 819-820. https://doi.org/10.1016/0140-6736(92)92687-B
Kinsella JP, Neish S, Shaffer E, Abman SH. Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. The Lancet. 1992 Oct 3;340(8823):819-820. https://doi.org/10.1016/0140-6736(92)92687-B
Kinsella, J. P. ; Neish, Steven ; Shaffer, E. ; Abman, S. H. / Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. In: The Lancet. 1992 ; Vol. 340, No. 8823. pp. 819-820.
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