Low cord blood levels of catecholamine from a newborn of a pheochromocytoma patient

Patricia L Dahia, C. Y. Hayashida, C. Strunz, N. Abelin, S. P A Toledo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Association of pheochromocytoma and pregnancy is rare and usually related to high maternal and fetal mortality rates. Maternal effects of the tumor have been studied extensively and the clinical outcome has markedly improved during the last decade. However, the role of excess catecholamines on fetal development has been discussed very little. We report here a case of pheochromocytoma during pregnancy, in which catecholamine levels from the cord blood were low despite simultaneous elevated maternal values (1.93 and 29.46 nmol/l norepinephrine, respectively), possibly owing to the high activity of the catecholamine degradative enzymes monoamine oxidase and COMT at the placental level. We suggest that in pregnancies complicated by pheochromocytoma, fetal well-being may be related mainly to good control of maternal blood pressure instead of to the amount of catecholamines in the fetal circulation, because the placenta performs a protective role through an effective process of hormone inactivation.

Original languageEnglish (US)
Pages (from-to)217-219
Number of pages3
JournalEuropean Journal of Endocrinology
Volume130
Issue number3
StatePublished - 1994
Externally publishedYes

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Pheochromocytoma
Fetal Blood
Catecholamines
Newborn Infant
Pregnancy
Mothers
Fetal Mortality
Maternal Mortality
Monoamine Oxidase
Fetal Development
Placenta
Norepinephrine
Hormones
Blood Pressure
Mortality
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Endocrinology

Cite this

Dahia, P. L., Hayashida, C. Y., Strunz, C., Abelin, N., & Toledo, S. P. A. (1994). Low cord blood levels of catecholamine from a newborn of a pheochromocytoma patient. European Journal of Endocrinology, 130(3), 217-219.

Low cord blood levels of catecholamine from a newborn of a pheochromocytoma patient. / Dahia, Patricia L; Hayashida, C. Y.; Strunz, C.; Abelin, N.; Toledo, S. P A.

In: European Journal of Endocrinology, Vol. 130, No. 3, 1994, p. 217-219.

Research output: Contribution to journalArticle

Dahia, PL, Hayashida, CY, Strunz, C, Abelin, N & Toledo, SPA 1994, 'Low cord blood levels of catecholamine from a newborn of a pheochromocytoma patient', European Journal of Endocrinology, vol. 130, no. 3, pp. 217-219.
Dahia, Patricia L ; Hayashida, C. Y. ; Strunz, C. ; Abelin, N. ; Toledo, S. P A. / Low cord blood levels of catecholamine from a newborn of a pheochromocytoma patient. In: European Journal of Endocrinology. 1994 ; Vol. 130, No. 3. pp. 217-219.
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