Low- and Conventional-Dose Maintenance Therapy With Fluphenazine Decanoate: Two-Year Outcome

Stephen R. Marder, Theodore Van Putten, Jim Mintz, Malca Lebell, Joanne Mckenzie, Philip R.A. May

Research output: Contribution to journalArticlepeer-review

167 Scopus citations

Abstract

We evaluated the effectiveness and the side effects of what we defined as low (5-mg) and conventional (25-mg) doses of fluphenazine decanoate administered every two weeks in a double-blind comparison. Subjects were 66 patients who fulfilled DSM-III criteria for schizophrenic disorder. Evaluation of the survival with each dose revealed no significant difference at one year, but significantly better survival was seen with the 25-mg dose (64%) than the 5-mg dose (31%) at two years. There was no significant difference in survival when the clinician was permitted to make a dosage adjustment up to 10 mg in the lowdose group and 50 mg in the higher-dose group when the patient demonstrated evidence of a symptomatic exacerbation. Patients assigned to the higher dose appeared to feel more uncomfortable during the early months of the study, as indicated by significantly higher scores on subscales of the Hopkins Symptom Checklist-90R and higher side effect scores for retardation and akathisia. Implications for clinical practice are discussed.

Original languageEnglish (US)
Pages (from-to)518-521
Number of pages4
JournalArchives of General Psychiatry
Volume44
Issue number6
DOIs
StatePublished - Jun 1987
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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