Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice

M. M. Miller, D. Joshi, R. B. Billiar, J. F. Nelson

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p < 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in order mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalNeurobiology of Aging
Issue number3
StatePublished - 1990
Externally publishedYes


  • Aging
  • Hypothalamus
  • Immunocytochemistry
  • Luteinizing-hormone releasing hormone
  • Mouse
  • Preoptic area

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • General Neuroscience
  • Developmental Biology


Dive into the research topics of 'Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice'. Together they form a unique fingerprint.

Cite this