Loss of in vitro resistance in Candida glabrata following discontinuation of fluconazole prophylaxis in a hematopoietic stem cell transplantation patient

Steven D. Westbrook, Nathan P. Wiederhold, Ana C. Vallor, Susann Kotara, Stella Bernardo, Samuel A. Lee, William R. Kirkpatrick, Juan J. Toro, Cesaro Freytes, Thomas F. Patterson, Spencer W. Redding

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We report a case of fluconazole-resistant oropharyngeal colonization caused by a strain of Candida glabrata that rapidly regained susceptibility once prophylaxis with this agent was discontinued and echinocandin therapy was initiated. Isolates collected before and after discontinuation of fluconazole were confirmed to be isogenic by RAPD analysis. Transcription analysis demonstrated constitutive expression of genes encoding efflux pumps in the isolate recovered on fluconazole prophylaxis and transient expression in those isolates collected after fluconazole was discontinued.

Original languageEnglish (US)
Pages (from-to)557-560
Number of pages4
JournalMedical mycology
Volume48
Issue number3
DOIs
StatePublished - Apr 14 2010

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Keywords

  • Candida glabrata
  • Fluconazole resistance
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Westbrook, S. D., Wiederhold, N. P., Vallor, A. C., Kotara, S., Bernardo, S., Lee, S. A., Kirkpatrick, W. R., Toro, J. J., Freytes, C., Patterson, T. F., & Redding, S. W. (2010). Loss of in vitro resistance in Candida glabrata following discontinuation of fluconazole prophylaxis in a hematopoietic stem cell transplantation patient. Medical mycology, 48(3), 557-560. https://doi.org/10.3109/13693780903213504