Loss of androgenic induction of α2u-globulin gene family in the liver of NIH black rats

B. Chatterjee, W. F. Demyan, C. S. Song, B. D. Garg, A. K. Roy

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Abstract

Unlike all known strains of rat, the androgeninducible α2u-globulin gene family is totally silent in the liver of NIH black (NB) rats. No endocrinological or reproductive abnormalities are apparent, and the mRNA for the androgenrepressible hepatic protein SMP-2 is normally regulated in these animals. Furthermore, immunoblot analysis shows a normal level of the male-specific cytoplasmic androgen-binding protein. Cross-breeding of the NB male and Sprague-Dawley female shows that the hybrid male in the F-l generation regains the androgen-dependent expression of α2u-globulin in the liver. These results along with the observation of high constitutive level ofα2u-globulin mRNA in the preputial gland of NB rats indicate a tissue- and gene-specific regulatory defect which prevents androgenic induction of α2u-globulin in the liver.

Original languageEnglish (US)
Pages (from-to)1385-1388
Number of pages4
JournalEndocrinology
Volume125
Issue number3
DOIs
Publication statusPublished - Sep 1989

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ASJC Scopus subject areas

  • Endocrinology

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