Loss of androgenic induction of α(2u)-globulin gene family in the liver of NIH black rats

Bandana Chatterjee, W. F. Demyan, Chung-seog Song, B. D. Garg, A. K. Roy

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Unlike all known strains of rat, the androgen-inducible α(2u)-globulin gene family is totally silent in the liver of NIH black (NB) rats. No endocrinological or reproductive abnormalities are apparent, and the mRNA for the androgen-repressible hepatic protein SMP-2 is normally regulated in these animals. Furthermore, immunoblot analysis shows a normal level of the male-specific cytoplasmic androgen-binding protein. Cross-breeding of the NB male and Sprague-Dawley female shows that the hybrid male in the F-1 generation regains the androgen-dependent expression of α(2u)-globulin in the liver. These results along with the observation of high constitutive level of α(2u)-globulin mRNA in the preputial gland of NB rats indicate a tissue- and gene-specific regulatory defect which prevents androgenic induction of α(2u)-globulin in the liver.

Original languageEnglish (US)
Pages (from-to)1385-1388
Number of pages4
JournalEndocrinology
Volume125
Issue number3
StatePublished - 1989

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Globulins
Androgens
Liver
Genes
Androgen-Binding Protein
Messenger RNA
Regulator Genes
Breeding
Observation
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Chatterjee, B., Demyan, W. F., Song, C., Garg, B. D., & Roy, A. K. (1989). Loss of androgenic induction of α(2u)-globulin gene family in the liver of NIH black rats. Endocrinology, 125(3), 1385-1388.

Loss of androgenic induction of α(2u)-globulin gene family in the liver of NIH black rats. / Chatterjee, Bandana; Demyan, W. F.; Song, Chung-seog; Garg, B. D.; Roy, A. K.

In: Endocrinology, Vol. 125, No. 3, 1989, p. 1385-1388.

Research output: Contribution to journalArticle

Chatterjee, B, Demyan, WF, Song, C, Garg, BD & Roy, AK 1989, 'Loss of androgenic induction of α(2u)-globulin gene family in the liver of NIH black rats', Endocrinology, vol. 125, no. 3, pp. 1385-1388.
Chatterjee, Bandana ; Demyan, W. F. ; Song, Chung-seog ; Garg, B. D. ; Roy, A. K. / Loss of androgenic induction of α(2u)-globulin gene family in the liver of NIH black rats. In: Endocrinology. 1989 ; Vol. 125, No. 3. pp. 1385-1388.
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