Lophocladines, bioactive alkaloids from the red alga lophocladia sp.

Harald Gross, Douglas E. Goeger, Patrice Hills, Susan L. Mooberry, David L. Ballantine, Thomas F. Murray, Frederick A. Valeriote, William H. Gerwick

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


Lophocladines A (1) and B (2), two 2,7-naphthyridine alkaloids, were isolated from the marine red alga Lophocladia sp. collected in the Fijian Islands. Their structures were deduced on the basis of high-resolution mass spectra and one- and two-dimensional NMR spectroscopy. Lophocladine A (1) displayed affinity for NMDA receptors and was found to be a δ-opioid receptor antagonist, whereas lophocladine B (2) exhibited cytotoxicity to NCI-H460 human lung tumor and MDA-MB-435 breast cancer cell lines. Immunofluorescence studies indicated that the cytotoxicity of lophocladine B (2) was correlated with microtubule inhibition. This is the first reported occurrence of alkaloids based on a 2,7- naphthyridine skeleton from red algae.

Original languageEnglish (US)
Pages (from-to)640-644
Number of pages5
JournalJournal of Natural Products
Issue number4
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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