Loop diuretics are K+-sparing in the presence of a low-Na+, high-K+ diet

Nina Boiko, Jonathan Berman, Elena Mironova, James D. Stockand

Research output: Contribution to journalComment/debate

1 Scopus citations


Under most conditions, loop diuretics are K+-wasting, requiring potassium supplementation. In this issue, Wang and colleagues demonstrate that in mice fed a low-Na+, high-K+ diet, loop diuretics, in contrast, are K+-sparing. This observation suggests that possible elevations in plasma K+ should be monitored when using a loop diuretic with a low-Na+, high-K+ diet, particularly when in combination with a potassium supplement.

Original languageEnglish (US)
Pages (from-to)786-787
Number of pages2
JournalKidney International
Issue number4
StatePublished - Oct 1 2017

ASJC Scopus subject areas

  • Nephrology

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