Looking Back at PCPT: Looking Forward to New Paradigms in Prostate Cancer Screening and Prevention{A figure is presented}

Edith Canby-Hagino, Javier Hernandez, Timothy C. Brand, Ian Thompson

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Objectives: Provide a critical summary of the latest interpretation of findings from the Prostate Cancer Prevention Trial (PCPT). Methods: Findings from PCPT and recently published post-hoc analyses are reviewed. Results: PCPT demonstrated that finasteride can reduce the prevalence of prostate cancer, permitted the first large-scale assessment of the performance characteristics of prostate-specific antigen for prostate cancer screening, and identified new-onset erectile dysfunction as an early predictor of cardiovascular events. Conclusions: PCPT has and will continue to yield valuable information regarding future strategies for prostate cancer prevention and detection, benign prostatic hyperplasia, and other matters of public health importance.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalEuropean Urology
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Finasteride
  • Prevention
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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