TY - JOUR
T1 - Longitudinal analysis of antigen specific response in individuals with schistosoma mansoni infection in an endemic area of Minas Gerais, Brazil
AU - Matoso, Leonardo Ferreira
AU - Oliveira-Prado, Roberta
AU - Abreu, Mery Natali Silva
AU - Fujiwara, Ricardo Toshio
AU - Loverde, Philip T.
AU - Kloos, Helmut
AU - Gazzinelli, Andréa
AU - Correa-Oliveira, Rodrigo
N1 - Funding Information:
Funding: Fundac¸ão de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil; Instituto Nacional de Ciência e Tecnologia de Doenc¸as Tropicais (INCT-DT), Belo Horizonte, MG, Brazil; National Institute of Health (NIH), Bethesda, MA, USA (Grant A145451 and Grant 1R03AI071057-01), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brasilia, Brazil.
PY - 2013/12
Y1 - 2013/12
N2 - Background: Immunoepidemiologic studies have shown a relationship between IgE and IgG4 antibodies with age and with resistance and susceptibility to infection. It is believed that the IgE and IgG4 responses to soluble egg antigen (SEA) can be used for serological analysis of infection and post-treatment status. This study aimed to evaluate the association between Schistosoma mansoni infection and anti-SEA IgG4 and IgE reactivities, and determine whether these reactivities could be used as biomarkers of infection. Methods: Between 2001 and 2009, a longitudinal study was performed in which parasitologic and blood specimens and socioeconomic and water-contact information were collected from 127 individuals. All patients positive for S. mansoni infection were treated. Results: Schistosomiasis prevalence and the geometric mean of the egg count in 2001 were 59% and 61.05, respectively, decreasing to 26.8% and 8.78 in 2009. IgG4 anti-SEA reactivity in infected individuals was significantly higher than that in uninfected individuals at all time points. Analysis of receiver-operating characteristic (ROC) area showed that the IgG4 anti-SEA antibodies were able to predict infection by S. mansoni at each time point. Conclusion: IgG4 anti-SEA reactivity can be used as a biomarker for immune monitoring of the presence of infection with S. mansoni in endemic areas.
AB - Background: Immunoepidemiologic studies have shown a relationship between IgE and IgG4 antibodies with age and with resistance and susceptibility to infection. It is believed that the IgE and IgG4 responses to soluble egg antigen (SEA) can be used for serological analysis of infection and post-treatment status. This study aimed to evaluate the association between Schistosoma mansoni infection and anti-SEA IgG4 and IgE reactivities, and determine whether these reactivities could be used as biomarkers of infection. Methods: Between 2001 and 2009, a longitudinal study was performed in which parasitologic and blood specimens and socioeconomic and water-contact information were collected from 127 individuals. All patients positive for S. mansoni infection were treated. Results: Schistosomiasis prevalence and the geometric mean of the egg count in 2001 were 59% and 61.05, respectively, decreasing to 26.8% and 8.78 in 2009. IgG4 anti-SEA reactivity in infected individuals was significantly higher than that in uninfected individuals at all time points. Analysis of receiver-operating characteristic (ROC) area showed that the IgG4 anti-SEA antibodies were able to predict infection by S. mansoni at each time point. Conclusion: IgG4 anti-SEA reactivity can be used as a biomarker for immune monitoring of the presence of infection with S. mansoni in endemic areas.
KW - Biomarkers
KW - IgE
KW - IgG4
KW - Immunoepidemiology
KW - Longitudinal study
KW - Schistosomiasis
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U2 - 10.1093/trstmh/trt091
DO - 10.1093/trstmh/trt091
M3 - Article
C2 - 24189480
AN - SCOPUS:84887864163
SN - 0035-9203
VL - 107
SP - 797
EP - 805
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 12
M1 - trt091
ER -