Long-term survival after surgical management of neuroendocrine hepatic metastases

Evan S. Glazer, Jennifer F. Tseng, Waddah Al-Refaie, Carmen C. Solorzano, Ping Liu, Katherine A. Willborn, Eddie K. Abdalla, Jean Nicolas Vauthey, Steven A. Curley

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Background: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. Methods: Patients (n = 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival. Results: The median age was 56.8 years (range 11.5-80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3-56.8, P = 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P ̃ 0.8). Discussion: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalHPB
Volume12
Issue number6
DOIs
StatePublished - Aug 2010

Keywords

  • Carcinoid
  • Liver metastases
  • Liver resection
  • Nneuroendocrine
  • Radiofrequency ablation
  • Survival

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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  • Cite this

    Glazer, E. S., Tseng, J. F., Al-Refaie, W., Solorzano, C. C., Liu, P., Willborn, K. A., Abdalla, E. K., Vauthey, J. N., & Curley, S. A. (2010). Long-term survival after surgical management of neuroendocrine hepatic metastases. HPB, 12(6), 427-433. https://doi.org/10.1111/j.1477-2574.2010.00198.x