Long-term outcomes from the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study

Roger D. Weiss, Jennifer Sharpe Potter, Margaret L. Griffin, Scott E. Provost, Garrett M. Fitzmaurice, Katherine A. McDermott, Emily N. Srisarajivakul, Dorian R. Dodd, Jessica A. Dreifuss, R. Kathryn McHugh, Kathleen M. Carroll

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Background: Despite the growing prevalence of prescription opioid dependence, longitudinal studies have not examined long-term treatment response. The current study examined outcomes over 42 months in the Prescription Opioid Addiction Treatment Study (POATS). Methods: POATS was a multi-site clinical trial lasting up to 9 months, examining different durations of buprenorphine-naloxone plus standard medical management for prescription opioid dependence, with participants randomized to receive or not receive additional opioid drug counseling. A subset of participants (N= 375 of 653) enrolled in a follow-up study. Telephone interviews were administered approximately 18, 30, and 42 months after main-trial enrollment. Comparison of baseline characteristics by follow-up participation suggested few differences. Results: At Month 42, much improvement was seen: 31.7% were abstinent from opioids and not on agonist therapy; 29.4% were receiving opioid agonist therapy, but met no symptom criteria for current opioid dependence; 7.5% were using illicit opioids while on agonist therapy; and the remaining 31.4% were using opioids without agonist therapy. Participants reporting a lifetime history of heroin use at baseline were more likely to meet DSM-IV criteria for opioid dependence at Month 42 (OR. = 4.56, 95% CI. = 1.29-16.04, p<. .05). Engagement in agonist therapy was associated with a greater likelihood of illicit-opioid abstinence. Eight percent (n= 27/338) used heroin for the first time during follow-up; 10.1% reported first-time injection heroin use. Conclusions: Long-term outcomes for those dependent on prescription opioids demonstrated clear improvement from baseline. However, a subset exhibited a worsening course, by initiating heroin use and/or injection opioid use.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalDrug and Alcohol Dependence
Volume150
DOIs
StatePublished - May 1 2015

Keywords

  • Addiction
  • Follow-up
  • Heroin
  • Opioids
  • Prescription opioids
  • Treatment

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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  • Cite this

    Weiss, R. D., Potter, J. S., Griffin, M. L., Provost, S. E., Fitzmaurice, G. M., McDermott, K. A., Srisarajivakul, E. N., Dodd, D. R., Dreifuss, J. A., McHugh, R. K., & Carroll, K. M. (2015). Long-term outcomes from the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study. Drug and Alcohol Dependence, 150, 112-119. https://doi.org/10.1016/j.drugalcdep.2015.02.030