Long-term efficacy and safety of botulinum toxin injections in dystonia

Juan Ramirez-Castaneda, Joseph Jankovic

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Local chemodenervation with botulinum toxin (BoNT) injections to relax abnormally contracting muscles has been shown to be an effective and well-tolerated treatment in a variety of movement disorders and other neurological and non-neurological disorders. Despite almost 30 years of therapeutic use, there are only few studies of patients treated with BoNT injections over long period of time. These published data clearly support the conclusion that BoNT not only provides safe and effective symptomatic relief of dystonia but also long-term benefit and possibly even favorably modifying the natural history of this disease. The adverse events associated with chronic, periodic exposure to BoNT injections are generally minor and self-limiting. With the chronic use of BoNT and an expanding list of therapeutic indications, there is a need to carefully examine the existing data on the long-term efficacy and safety of BoNT. In this review we will highlight some of the aspects of long-term effects of BoNT, including efficacy, safety, and immunogenicity.

Original languageEnglish (US)
Pages (from-to)249-266
Number of pages18
JournalToxins
Volume5
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Keywords

  • Botulinum toxin
  • Dystonia
  • Efficacy
  • Long-term
  • Safety

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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