Long-term changes in adiposity and glycemic control are associated with past adenovirus infection

Wan Yu Lin, Olga Dubuisson, Rohina Rubicz, Nianjun Liu, David B. Allison, Joanne E. Curran, Anthony G. Comuzzie, John Blangero, Charles T. Leach, Harald Göring, Nikhil V. Dhurandhar

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

OBJECTIVEdAd36, a human adenovirus, increases adiposity but improves glycemic control in animal models. Similarly, natural Ad36 infection is cross-sectionally associated with greater adiposity and better glycemic control in humans. This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults. RESEARCH DESIGN ANDMETHODSdBaseline sera from Hispanic men and women (n = 1,400) were screened post hoc for the presence of Ad36-specific antibodies. Indices of adiposity and glycemic control at baseline and at ;10 years past the baseline were compared between seropositive and seronegative subjects, with adjustment for age and sex. In addition to age and sex, indices of glycemic control were adjusted for baseline BMI and were analyzed only for nondiabetic subjects. RESULTSdSeropositive subjects (14.5%) had greater adiposity at baseline, compared with seronegative subjects. Longitudinally, seropositive subjects showed greater adiposity indices but lower fasting insulin levels. Subgroup analyses revealed that Ad36-seropositivity was associated with better baseline glycemic control and lower fasting insulin levels over time in the normalweight group (BMI<25 kg/m2) and longitudinally,with greater adiposity in the overweight (BMI 25-30 kg/m2) and obese (BMI >30 kg/m2) men. Statistically, the differences between seropositive and seronegative individuals were modest in light of the multiple tests performed. CONCLUSIONSdThis study strengthens the plausibility that in humans, Ad36 increases adiposity and attenuates deterioration of glycemic control. Panoptically, the study raises the possibility that certain infections may modulate obesity or diabetes risk. A comprehensive understanding of these under-recognized factors is needed to effectively combat such metabolic disorders.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalDiabetes Care
Volume36
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

Fingerprint

Adenoviridae Infections
Adiposity
Glycemic Index
Fasting
Insulin
Human Adenoviruses
Cross Infection
Hispanic Americans
Longitudinal Studies
Adipose Tissue
Animal Models
Obesity
Glucose
Antibodies
Infection
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Lin, W. Y., Dubuisson, O., Rubicz, R., Liu, N., Allison, D. B., Curran, J. E., ... Dhurandhar, N. V. (2013). Long-term changes in adiposity and glycemic control are associated with past adenovirus infection. Diabetes Care, 36(3), 701-707. https://doi.org/10.2337/dc12-1089

Long-term changes in adiposity and glycemic control are associated with past adenovirus infection. / Lin, Wan Yu; Dubuisson, Olga; Rubicz, Rohina; Liu, Nianjun; Allison, David B.; Curran, Joanne E.; Comuzzie, Anthony G.; Blangero, John; Leach, Charles T.; Göring, Harald; Dhurandhar, Nikhil V.

In: Diabetes Care, Vol. 36, No. 3, 03.2013, p. 701-707.

Research output: Contribution to journalArticle

Lin, WY, Dubuisson, O, Rubicz, R, Liu, N, Allison, DB, Curran, JE, Comuzzie, AG, Blangero, J, Leach, CT, Göring, H & Dhurandhar, NV 2013, 'Long-term changes in adiposity and glycemic control are associated with past adenovirus infection', Diabetes Care, vol. 36, no. 3, pp. 701-707. https://doi.org/10.2337/dc12-1089
Lin, Wan Yu ; Dubuisson, Olga ; Rubicz, Rohina ; Liu, Nianjun ; Allison, David B. ; Curran, Joanne E. ; Comuzzie, Anthony G. ; Blangero, John ; Leach, Charles T. ; Göring, Harald ; Dhurandhar, Nikhil V. / Long-term changes in adiposity and glycemic control are associated with past adenovirus infection. In: Diabetes Care. 2013 ; Vol. 36, No. 3. pp. 701-707.
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abstract = "OBJECTIVEdAd36, a human adenovirus, increases adiposity but improves glycemic control in animal models. Similarly, natural Ad36 infection is cross-sectionally associated with greater adiposity and better glycemic control in humans. This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults. RESEARCH DESIGN ANDMETHODSdBaseline sera from Hispanic men and women (n = 1,400) were screened post hoc for the presence of Ad36-specific antibodies. Indices of adiposity and glycemic control at baseline and at ;10 years past the baseline were compared between seropositive and seronegative subjects, with adjustment for age and sex. In addition to age and sex, indices of glycemic control were adjusted for baseline BMI and were analyzed only for nondiabetic subjects. RESULTSdSeropositive subjects (14.5{\%}) had greater adiposity at baseline, compared with seronegative subjects. Longitudinally, seropositive subjects showed greater adiposity indices but lower fasting insulin levels. Subgroup analyses revealed that Ad36-seropositivity was associated with better baseline glycemic control and lower fasting insulin levels over time in the normalweight group (BMI<25 kg/m2) and longitudinally,with greater adiposity in the overweight (BMI 25-30 kg/m2) and obese (BMI >30 kg/m2) men. Statistically, the differences between seropositive and seronegative individuals were modest in light of the multiple tests performed. CONCLUSIONSdThis study strengthens the plausibility that in humans, Ad36 increases adiposity and attenuates deterioration of glycemic control. Panoptically, the study raises the possibility that certain infections may modulate obesity or diabetes risk. A comprehensive understanding of these under-recognized factors is needed to effectively combat such metabolic disorders.",
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T1 - Long-term changes in adiposity and glycemic control are associated with past adenovirus infection

AU - Lin, Wan Yu

AU - Dubuisson, Olga

AU - Rubicz, Rohina

AU - Liu, Nianjun

AU - Allison, David B.

AU - Curran, Joanne E.

AU - Comuzzie, Anthony G.

AU - Blangero, John

AU - Leach, Charles T.

AU - Göring, Harald

AU - Dhurandhar, Nikhil V.

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N2 - OBJECTIVEdAd36, a human adenovirus, increases adiposity but improves glycemic control in animal models. Similarly, natural Ad36 infection is cross-sectionally associated with greater adiposity and better glycemic control in humans. This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults. RESEARCH DESIGN ANDMETHODSdBaseline sera from Hispanic men and women (n = 1,400) were screened post hoc for the presence of Ad36-specific antibodies. Indices of adiposity and glycemic control at baseline and at ;10 years past the baseline were compared between seropositive and seronegative subjects, with adjustment for age and sex. In addition to age and sex, indices of glycemic control were adjusted for baseline BMI and were analyzed only for nondiabetic subjects. RESULTSdSeropositive subjects (14.5%) had greater adiposity at baseline, compared with seronegative subjects. Longitudinally, seropositive subjects showed greater adiposity indices but lower fasting insulin levels. Subgroup analyses revealed that Ad36-seropositivity was associated with better baseline glycemic control and lower fasting insulin levels over time in the normalweight group (BMI<25 kg/m2) and longitudinally,with greater adiposity in the overweight (BMI 25-30 kg/m2) and obese (BMI >30 kg/m2) men. Statistically, the differences between seropositive and seronegative individuals were modest in light of the multiple tests performed. CONCLUSIONSdThis study strengthens the plausibility that in humans, Ad36 increases adiposity and attenuates deterioration of glycemic control. Panoptically, the study raises the possibility that certain infections may modulate obesity or diabetes risk. A comprehensive understanding of these under-recognized factors is needed to effectively combat such metabolic disorders.

AB - OBJECTIVEdAd36, a human adenovirus, increases adiposity but improves glycemic control in animal models. Similarly, natural Ad36 infection is cross-sectionally associated with greater adiposity and better glycemic control in humans. This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults. RESEARCH DESIGN ANDMETHODSdBaseline sera from Hispanic men and women (n = 1,400) were screened post hoc for the presence of Ad36-specific antibodies. Indices of adiposity and glycemic control at baseline and at ;10 years past the baseline were compared between seropositive and seronegative subjects, with adjustment for age and sex. In addition to age and sex, indices of glycemic control were adjusted for baseline BMI and were analyzed only for nondiabetic subjects. RESULTSdSeropositive subjects (14.5%) had greater adiposity at baseline, compared with seronegative subjects. Longitudinally, seropositive subjects showed greater adiposity indices but lower fasting insulin levels. Subgroup analyses revealed that Ad36-seropositivity was associated with better baseline glycemic control and lower fasting insulin levels over time in the normalweight group (BMI<25 kg/m2) and longitudinally,with greater adiposity in the overweight (BMI 25-30 kg/m2) and obese (BMI >30 kg/m2) men. Statistically, the differences between seropositive and seronegative individuals were modest in light of the multiple tests performed. CONCLUSIONSdThis study strengthens the plausibility that in humans, Ad36 increases adiposity and attenuates deterioration of glycemic control. Panoptically, the study raises the possibility that certain infections may modulate obesity or diabetes risk. A comprehensive understanding of these under-recognized factors is needed to effectively combat such metabolic disorders.

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