Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6

Candace M. Kammerer, David L. Rainwater, Laura A. Cox, Jennifer L. Schneider, Michael C. Mahaney, Jeffrey Rogers, John L. VandeBerg

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations

    Abstract

    Objective - Cholesterolemic responses to dietary lipids are known to be heritable, but the genes that may affect this response have yet to be identified. Using segregation analysis, we previously detected a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map. Methods and Results - We obtained evidence for linkage of this potential QTL to the same locus (D6S311) on the baboon homologue of human chromosome 6 by using variance components and parametric linkage analysis methods (2-point lod scores 4.17 [genomic probability value 0.008] and 2.81 [genomic P=0.10], respectively). Linkage analyses of serum levels of apolipoprotein B dietary response, a correlated trait, also gave weak suggestive evidence of linkage to this chromosomal region (maximum 2-point lod score 1.91). Although the LPA locus is nearby, we found no evidence of linkage with LPA. Conclusions - This report is the first to localize, in any primate species, a potential QTL that influences low density lipoprotein cholesterol response to dietary cholesterol.

    Original languageEnglish (US)
    Pages (from-to)1720-1725
    Number of pages6
    JournalArteriosclerosis, Thrombosis, and Vascular Biology
    Volume22
    Issue number10
    DOIs
    StatePublished - Oct 1 2002

    Keywords

    • Baboons
    • Diet
    • LDL
    • Linkage

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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