Localized Photothermal Ablation Therapy of Obstructive Rectal Cancer Using a Nanofunctionalized Stent in a Mouse Model

Hong Tao Hu, Jung Hoon Park, Zhe Wang, Nader Bakheet, Shi Jun Xu, Eun Ji Lee, Dong Hyun Kim, Song Hee Kim, Ho Young Song, Jae Yong Jeon, Suhwan Chang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The self-expanding metal stent (SEMS) is a versatile, palliative treatment method for unresectable, malignant, non-vascular strictures. Colorectal cancer (CRC) is one of the candidates for the application of the SEMS, in combination with the photothermal ablation (PTA) technique that enhances its therapeutic efficacy. The objective of this study was to investigate the efficacy of stent-mediated PTA therapy in an endoscopy-guided, orthotopic rectal cancer model. A total of 30 of 40 mice with the tumor size of grade 4 were included and were divided into three groups of 10 mice each. Group A underwent a gold nanoparticle (AuNP)-coated SEMS but no near-infrared (NIR) irradiation, group B received an uncoated control SEMS with NIR irradiation, and group C received a AuNP-coated SEMS and NIR irradiation together. Colonoscopy and in vivo imaging, immunohistochemical analysis, and quantitative reverse-transcription polymerase chain reaction of major tumor markers were performed. Stent placement and PTA were technically successful using colonoscopy. The tumor grade reduction after PTA is significant in group C, compared with groups A or B (p < 0.001). Molecular analysis validated this observation with a significantly reduced Mapk1 proliferation marker or increased Jnk expression. Histological analysis confirmed the localized PTA therapy using AuNP-coated SEMS profoundly ablated tumor outgrowth through the stent. Our results indicate that this novel strategy of localized PTA therapy could be a promising option for palliative treatment of CRC and to support prolonged stent patency with a decreased tumor volume.

Original languageEnglish (US)
Pages (from-to)5890-5898
Number of pages9
JournalACS Biomaterials Science and Engineering
Issue number12
StatePublished - Dec 13 2021


  • colorectal cancer
  • gold nanoparticle
  • orthotopic colon cancer model
  • photothermal ablation
  • self-expandable metallic stent

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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