Localization of the Nav1.8 sodium channel isoform at nodes of Ranvier in normal human radicular tooth pulp

Michael A. Henry, Howard J. Sorensen, Lonnie R. Johnson, S. Rock Levinson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The activation of voltage-gated sodium channels is necessary for action potential propagation and multiple sodium channel isoforms have been identified that show a differential distribution throughout the nervous system. An evaluation of sodium channel localization in the radicular pulp from normal human extracted third molars established the presence of the Nav1.8 isoform at nodes of Ranvier in a subpopulation of the myelinated axons as demonstrated with immunofluorescence confocal microscopy. A caspr antibody was used to identify the paranodal region of nodes of Ranvier and quantitative analysis revealed that 16.5% of the nodes contained significant Na v1.8 immunoreactivity. Since the Nav1.6 isoform has been described as the predominant sodium channel at essentially all nodes, the finding of Nav1.8 in a subpopulation of nodes suggests that multiple isoforms may coexist at some nodes of Ranvier and also suggests that this isoform may be an important nodal sodium channel type in the peripheral sensory nervous system of humans.

Original languageEnglish (US)
Pages (from-to)32-36
Number of pages5
JournalNeuroscience Letters
Volume380
Issue number1-2
DOIs
StatePublished - May 20 2005

Keywords

  • Caspr
  • Human
  • Na1.8
  • Nodes of Ranvier
  • Sodium channels
  • Tooth pulp

ASJC Scopus subject areas

  • Neuroscience(all)

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