Localization of the cell attachment region in types I and II collagens

Hynda K. Kleinman, Ermona B. McGoodwin, Robert J. Klebe

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

The sites on type I and II collagen which bind to the cell attachment protein (CAP) have been identified using an inhibition assay. Both chains of type I collagen contain binding sites but αI(I) is more active than the α2 chain. The most active peptide obtained from the α1(I) chain corresponds to residues 568 through 835. A comparable region was found to be the only active site on the α1 (II) chain.

Original languageEnglish (US)
Pages (from-to)426-432
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume72
Issue number2
DOIs
StatePublished - Sep 20 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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