Localization of progestin receptors in the islets of langerhans

William B. Winborn, Peter J. Sheridan, Henry C. McGill

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Autoradiographic studies using the synthetic progestin [3H]ORG-2058 (16α-ethyl-21-hydroxy-19-nor-[6,7-3H]pregn-4-ene-3,20-dione) were conducted on female baboons. Numerous silver grains from the exposed photographic emulsion appeared discretely localized over the nuclei of the islets of Langerhans of the pancreases of baboons injected with [3H]ORG-2058. These observations indicate that islet cells might contain receptors for progestins and, combined with clinical observations by others, suggest that progestins have a direct effect on the islet cells and may modulate the release of insulin and/or other islet hormones.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalPancreas
Volume2
Issue number3
DOIs
StatePublished - May 1987
Externally publishedYes

Keywords

  • Baboons
  • Estrogens
  • Insulin
  • Oral Contraceptives
  • ORG-2058
  • Pancreatic islets
  • Primates
  • Steroid receptors
  • Tritiated steroids

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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