Localization of progestin receptors in the islets of langerhans

William B. Winborn, Peter J. Sheridan, Henry C. McGill

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Autoradiographic studies using the synthetic progestin [3H]ORG-2058 (16α-ethyl-21-hydroxy-19-nor-[6,7-3H]pregn-4-ene-3,20-dione) were conducted on female baboons. Numerous silver grains from the exposed photographic emulsion appeared discretely localized over the nuclei of the islets of Langerhans of the pancreases of baboons injected with [3H]ORG-2058. These observations indicate that islet cells might contain receptors for progestins and, combined with clinical observations by others, suggest that progestins have a direct effect on the islet cells and may modulate the release of insulin and/or other islet hormones.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
Issue number3
StatePublished - May 1987
Externally publishedYes


  • Baboons
  • Estrogens
  • Insulin
  • Oral Contraceptives
  • ORG-2058
  • Pancreatic islets
  • Primates
  • Steroid receptors
  • Tritiated steroids

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


Dive into the research topics of 'Localization of progestin receptors in the islets of langerhans'. Together they form a unique fingerprint.

Cite this