Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides

Sarah Williams-Blangero, John L. VandeBerg, Janardan Subedi, Bharat Jha, Rodrigo Corrêa-Oliveira, John Blangero

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalJournal of Infectious Diseases
Volume197
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Ascaris lumbricoides
Quantitative Trait Loci
Odds Ratio
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 1
Infection
Nepal
Helminths
Pedigree
Soil
Genome
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Williams-Blangero, S., VandeBerg, J. L., Subedi, J., Jha, B., Corrêa-Oliveira, R., & Blangero, J. (2008). Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. Journal of Infectious Diseases, 197(1), 66-71. https://doi.org/10.1086/524060

Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. / Williams-Blangero, Sarah; VandeBerg, John L.; Subedi, Janardan; Jha, Bharat; Corrêa-Oliveira, Rodrigo; Blangero, John.

In: Journal of Infectious Diseases, Vol. 197, No. 1, 01.01.2008, p. 66-71.

Research output: Contribution to journalArticle

Williams-Blangero, S, VandeBerg, JL, Subedi, J, Jha, B, Corrêa-Oliveira, R & Blangero, J 2008, 'Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides', Journal of Infectious Diseases, vol. 197, no. 1, pp. 66-71. https://doi.org/10.1086/524060
Williams-Blangero, Sarah ; VandeBerg, John L. ; Subedi, Janardan ; Jha, Bharat ; Corrêa-Oliveira, Rodrigo ; Blangero, John. / Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. In: Journal of Infectious Diseases. 2008 ; Vol. 197, No. 1. pp. 66-71.
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