Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides

Sarah Williams-Blangero; John L. VandeBerg; Janardan Subedi; Bharat Jha; Rodrigo Corrêa-Oliveira; John Blangero

doi:10.1086/524060

Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides

Sarah Williams-Blangero, John L. VandeBerg, Janardan Subedi, Bharat Jha, Rodrigo Corrêa-Oliveira, John Blangero

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.

Original language	English (US)
Pages (from-to)	66-71
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	197
Issue number	1
DOIs	https://doi.org/10.1086/524060
State	Published - Jan 1 2008

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. / Williams-Blangero, Sarah; VandeBerg, John L.; Subedi, Janardan; Jha, Bharat; Corrêa-Oliveira, Rodrigo; Blangero, John.

In: Journal of Infectious Diseases, Vol. 197, No. 1, 01.01.2008, p. 66-71.

Research output: Contribution to journal › Article › peer-review

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abstract = "A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.",

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