Abstract
A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 66-71 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 197 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
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Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. / Williams-Blangero, Sarah; VandeBerg, John L.; Subedi, Janardan; Jha, Bharat; Corrêa-Oliveira, Rodrigo; Blangero, John.
In: Journal of Infectious Diseases, Vol. 197, No. 1, 01.01.2008, p. 66-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides
AU - Williams-Blangero, Sarah
AU - VandeBerg, John L.
AU - Subedi, Janardan
AU - Jha, Bharat
AU - Corrêa-Oliveira, Rodrigo
AU - Blangero, John
PY - 2008/1/1
Y1 - 2008/1/1
N2 - A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
AB - A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
UR - http://www.scopus.com/inward/record.url?scp=39349096914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39349096914&partnerID=8YFLogxK
U2 - 10.1086/524060
DO - 10.1086/524060
M3 - Article
VL - 197
SP - 66
EP - 71
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -