TY - JOUR
T1 - Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides
AU - Williams-Blangero, Sarah
AU - VandeBerg, John L.
AU - Subedi, Janardan
AU - Jha, Bharat
AU - Corrêa-Oliveira, Rodrigo
AU - Blangero, John
N1 - Funding Information:
Financial support: National Institutes of Health (NIH; grants AI37091 and AI44406 to S.W.B.). The statistical methods applied in the study were developed under NIH grant MH59490 (to J.B.). The research was conducted in part in facilities constructed with support from NIH grants C06 RR017515 and C06 RR13556.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
AB - A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
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U2 - 10.1086/524060
DO - 10.1086/524060
M3 - Article
C2 - 18171287
AN - SCOPUS:39349096914
VL - 197
SP - 66
EP - 71
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -