Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons

David L. Rainwater, Laura A. Cox, Jeffrey Rogers, John L. VandeBerg, Michae L.C. Mahamey

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    We employed a novel approach to identify the key loci that harbor genes influencing lipoprotein metabolism in approximately 2,000 pedigreed baboons fed various diets differing in levels of fat and cholesterol. In this study, 126 overlapping traits related to both LDL and HDL metabolism were normalized and subjected to genome-wide linkage screening. As was expected, the traits were highly, but not completely, correlated. We exploited the information in these correlated traits by focusing on those genomic regions harboring quantitative trait loci (QTL) for multiple traits, reasoning that the more influential genes would impact a larger number of traits. This study identified five major QTL clusters (each with at least two significant logarithm of the odds scores >4.7), two of which had not been previously reported in baboons. One of these mapped to the baboon ortholog of human chromosome 1p32-p34 and influenced concentrations of LDL-cholesterol on Basal and high-fat, low-cholesterol diets. The other novel QTL cluster mapped to the baboon ortholog of human chromosome 12q13.13-q14.1 and influenced LDL size properties on highfat, low-cholesterol and high-fat, high-cholesterol, but not Basal, diets. Confirming the value of this approach, three of the QTL clusters replicated published linkage findings for the same or similar traits.

    Original languageEnglish (US)
    Pages (from-to)1420-1428
    Number of pages9
    JournalJournal of lipid research
    Volume50
    Issue number7
    DOIs
    StatePublished - Jul 2009

    Keywords

    • Genetic
    • Linkage analysis
    • Primate
    • Quantitative trait locus

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Cell Biology

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