Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24

T. B. Lewis; S. Wood; E. K. Michaelis; B. R. Dupont; R. J. Leach

doi:10.1006/geno.1996.0088

Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24

T. B. Lewis, S. Wood, E. K. Michaelis, B. R. Dupont, R. J. Leach

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

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Abstract

A glutamate binding subunit gene, GRINA, has been previously mapped to human chromosome 8. A form of inherited epilepsy, benign familial neonatal convulsions (BFNC), has also been localized to chromosome 8. As NMDA receptors have been implicated in the pathogenesis of epilepsy, we were interested in determining whether GRINA mapped to the same region of chromosome 8 as BFNC. Fluorescence in situ hybridization localized GRINA to band 8q24, distal to the thyroglobulin gene. The strongest signal was seen at 8q24.3. A panel of 97 radiation hybrids (RH) was used to verify the localization. The RH mapping results placed GRINA as the most telomeric marker on our map of 8q24, distal to the interval defined for BFNC.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	Genomics
Volume	32
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0088
State	Published - Feb 15 1996

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0088

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title = "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24",

abstract = "A glutamate binding subunit gene, GRINA, has been previously mapped to human chromosome 8. A form of inherited epilepsy, benign familial neonatal convulsions (BFNC), has also been localized to chromosome 8. As NMDA receptors have been implicated in the pathogenesis of epilepsy, we were interested in determining whether GRINA mapped to the same region of chromosome 8 as BFNC. Fluorescence in situ hybridization localized GRINA to band 8q24, distal to the thyroglobulin gene. The strongest signal was seen at 8q24.3. A panel of 97 radiation hybrids (RH) was used to verify the localization. The RH mapping results placed GRINA as the most telomeric marker on our map of 8q24, distal to the interval defined for BFNC.",

author = "Lewis, {T. B.} and S. Wood and Michaelis, {E. K.} and Dupont, {B. R.} and Leach, {R. J.}",

note = "Funding Information: We thank M. Schertzer for technical assistance and M. Lewis for graphical assistance. This study was supported in part by the Canadian Genome Analysis and Technology Program Research Grant GO-12753 (S.W.) and by Grant PO1 HG00470 from the National Center for Human Genome Research (T.B.L., R.J.L.).",

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AU - Lewis, T. B.

AU - Wood, S.

AU - Michaelis, E. K.

AU - Dupont, B. R.

AU - Leach, R. J.

N1 - Funding Information: We thank M. Schertzer for technical assistance and M. Lewis for graphical assistance. This study was supported in part by the Canadian Genome Analysis and Technology Program Research Grant GO-12753 (S.W.) and by Grant PO1 HG00470 from the National Center for Human Genome Research (T.B.L., R.J.L.).

PY - 1996/2/15

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N2 - A glutamate binding subunit gene, GRINA, has been previously mapped to human chromosome 8. A form of inherited epilepsy, benign familial neonatal convulsions (BFNC), has also been localized to chromosome 8. As NMDA receptors have been implicated in the pathogenesis of epilepsy, we were interested in determining whether GRINA mapped to the same region of chromosome 8 as BFNC. Fluorescence in situ hybridization localized GRINA to band 8q24, distal to the thyroglobulin gene. The strongest signal was seen at 8q24.3. A panel of 97 radiation hybrids (RH) was used to verify the localization. The RH mapping results placed GRINA as the most telomeric marker on our map of 8q24, distal to the interval defined for BFNC.

AB - A glutamate binding subunit gene, GRINA, has been previously mapped to human chromosome 8. A form of inherited epilepsy, benign familial neonatal convulsions (BFNC), has also been localized to chromosome 8. As NMDA receptors have been implicated in the pathogenesis of epilepsy, we were interested in determining whether GRINA mapped to the same region of chromosome 8 as BFNC. Fluorescence in situ hybridization localized GRINA to band 8q24, distal to the thyroglobulin gene. The strongest signal was seen at 8q24.3. A panel of 97 radiation hybrids (RH) was used to verify the localization. The RH mapping results placed GRINA as the most telomeric marker on our map of 8q24, distal to the interval defined for BFNC.

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Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24

Abstract

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