Localization and identification of human quantitative trait loci: King Harvest has surely come

John Blangero

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The scientific process of localization and subsequent identification of genes influencing risk of common diseases is still in its infancy. Initial localization of disease-related loci has traditionally been performed using family-based linkage methods to scan the genome. Early pronouncements of the failure of this approach for common diseases were premature and based on comparing suboptimal linkage designs with overly optimistic and empirically unproven association-based designs. On the contrary, substantial recent progress in the positional cloning of genes influencing such complex phenotypes suggests that modern approaches based around a family-based linkage paradigm will be successful. In particular, the rapidly growing emphasis on the analysis of the genetic basis of quantitative correlates of disease risk represents a novel and promising approach in which initial localization is performed using linkage and subsequent identification utilizes association approaches in positional candidate genes.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume14
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Forensic Anthropology
Quantitative Trait Loci
Genes
Organism Cloning
Genome
Phenotype

Keywords

  • affected sib pair
  • ASP
  • Haplotype Map
  • HapMap
  • LD
  • linkage disequilibrium
  • QTL
  • QTN
  • quantitative trait locus
  • quantitative trait nucleotide
  • single nucleotide polymorphism
  • SNP

ASJC Scopus subject areas

  • Genetics

Cite this

Localization and identification of human quantitative trait loci : King Harvest has surely come. / Blangero, John.

In: Current Opinion in Genetics and Development, Vol. 14, No. 3, 06.2004, p. 233-240.

Research output: Contribution to journalArticle

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