Localization and identification of human quantitative trait loci: King Harvest has surely come

John Blangero

    Research output: Contribution to journalReview article

    85 Scopus citations

    Abstract

    The scientific process of localization and subsequent identification of genes influencing risk of common diseases is still in its infancy. Initial localization of disease-related loci has traditionally been performed using family-based linkage methods to scan the genome. Early pronouncements of the failure of this approach for common diseases were premature and based on comparing suboptimal linkage designs with overly optimistic and empirically unproven association-based designs. On the contrary, substantial recent progress in the positional cloning of genes influencing such complex phenotypes suggests that modern approaches based around a family-based linkage paradigm will be successful. In particular, the rapidly growing emphasis on the analysis of the genetic basis of quantitative correlates of disease risk represents a novel and promising approach in which initial localization is performed using linkage and subsequent identification utilizes association approaches in positional candidate genes.

    Original languageEnglish (US)
    Pages (from-to)233-240
    Number of pages8
    JournalCurrent Opinion in Genetics and Development
    Volume14
    Issue number3
    DOIs
    StatePublished - Jun 1 2004

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    Keywords

    • ASP
    • HapMap
    • Haplotype Map
    • LD
    • QTL
    • QTN
    • SNP
    • affected sib pair
    • linkage disequilibrium
    • quantitative trait locus
    • quantitative trait nucleotide
    • single nucleotide polymorphism

    ASJC Scopus subject areas

    • Genetics
    • Developmental Biology

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