Local ocular safety of the subconjunctival injection of cetuximab in rabbits

Hossein Aghaei; Ahmad Kheirkhah; Ali Mohammad Alizadeh; Acieh Es’haghi; Roshanak Aliakbar-Navahi; Zahra Keikha; Samira Chaibakhsh

doi:10.1186/s12886-023-02893-6

Local ocular safety of the subconjunctival injection of cetuximab in rabbits

Hossein Aghaei, Ahmad Kheirkhah, Ali Mohammad Alizadeh, Acieh Es’haghi, Roshanak Aliakbar-Navahi, Zahra Keikha, Samira Chaibakhsh

Research output: Contribution to journal › Article › peer-review

Abstract

Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.

Original language	English (US)
Article number	155
Journal	BMC Ophthalmology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12886-023-02893-6
State	Published - Dec 2023
Externally published	Yes

Keywords

Cetuximab
Intraepithelial neoplasia
Ocular surface squamous neoplasia

ASJC Scopus subject areas

Ophthalmology

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10.1186/s12886-023-02893-6

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title = "Local ocular safety of the subconjunctival injection of cetuximab in rabbits",

abstract = "Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.",

keywords = "Cetuximab, Intraepithelial neoplasia, Ocular surface squamous neoplasia",

author = "Hossein Aghaei and Ahmad Kheirkhah and Alizadeh, {Ali Mohammad} and Acieh Es{\textquoteright}haghi and Roshanak Aliakbar-Navahi and Zahra Keikha and Samira Chaibakhsh",

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doi = "10.1186/s12886-023-02893-6",

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AU - Aghaei, Hossein

AU - Kheirkhah, Ahmad

AU - Alizadeh, Ali Mohammad

AU - Es’haghi, Acieh

AU - Aliakbar-Navahi, Roshanak

AU - Keikha, Zahra

AU - Chaibakhsh, Samira

PY - 2023/12

Y1 - 2023/12

N2 - Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.

AB - Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.

KW - Cetuximab

KW - Intraepithelial neoplasia

KW - Ocular surface squamous neoplasia

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ER -

Local ocular safety of the subconjunctival injection of cetuximab in rabbits

Abstract

Keywords

ASJC Scopus subject areas

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