Local melatoninergic system as the protector of skin integrity

Andrzej T. Slominski, Konrad Kleszczyński, Igor Semak, Zorica Janjetovic, Michał A. Żmijewski, Tae Kang Kim, Radomir M. Slominski, Russel J. Reiter, Tobias W. Fischer

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

The human skin is not only a target for the protective actions of melatonin, but also a site of melatonin synthesis and metabolism, suggesting an important role for a local melatoninergic system in protection against ultraviolet radiation (UVR) induced damages. While melatonin exerts many effects on cell physiology and tissue homeostasis via membrane bound melatonin receptors, the strong protective effects of melatonin against the UVR-induced skin damage including DNA repair/protection seen at its high (pharmocological) concentrations indicate that these are mainly mediated through receptor-independent mechanisms or perhaps through activation of putative melatonin nuclear receptors. The destructive effects of the UVR are significantly counteracted or modulated by melatonin in the context of a complex intracutaneous melatoninergic anti-oxidative system with UVR-enhanced or UVR-independent melatonin metabolites. Therefore, endogenous intracutaneous melatonin production, together with topically-applied exogenous melatonin or metabolites would be expected to represent one of the most potent anti-oxidative defense systems against the UV-induced damage to the skin. In summary, we propose that melatonin can be exploited therapeutically as a protective agent or as a survival factor with anti-genotoxic properties or as a “guardian” of the genome and cellular integrity with clinical applications in UVR-induced pathology that includes carcinogenesis and skin aging.

Original languageEnglish (US)
Pages (from-to)17705-17732
Number of pages28
JournalInternational journal of molecular sciences
Volume15
Issue number10
DOIs
StatePublished - Sep 30 2014

Keywords

  • 6-hydroxymelatonin
  • AFMK
  • Human full-thickness skin
  • Keratinocytes
  • Melatonin
  • Oxidative stress
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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