BACKGROUND: Endothelial hyperplasia contributes to the restenosis following coronary stent implantation. Low molecular weight heparin has the potential to prevent endothelial growth, when administered locally at the site of stent implantation. AIM: The purpose of this study was to evaluate the acute feasibility and short-term outcome of local intramural delivery of low molecular weight heparin during coronary stent implantation. METHODS: Twenty eight patients scheduled for single lesion angioplasty were included in the study. Before the procedure 5000 units of heparin was administered iv. Following the predilatation with Transport F/X catheter, 10 mg enoxaparin was delivered locally at pressure of 3-4 atm. Afterwards coronary stent (Palmaz- Schatz stent in 14 cases and NIR stent in 14 cases) was implanted (at 16,1±2,3 atm). Arterial sheaths were removed within one hour after procedure and all patients were ambulated up to 8 hours. RESULTS: All procedures were successful and no acute complications were observed during hospitalization. There were no cardiac events during 3 month follow up. 6 months results will follow. CONCLUSION: Our preliminary experience shows that local drug delivery during stent implantation is a safe procedure, and may thus serve as a model for further studies on prevention of restenosis.
|Translated title of the contribution||Local intramural delivery of low molecular weight heparin during coronary stent implantation - Preliminary report|
|Number of pages||5|
|State||Published - Jan 1 1998|
- Coronary stent
- Local drug delivery
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine