Liver tumors in children

Jason B. Litten, Gail E. Tomlinson

Research output: Contribution to journalReview articlepeer-review

179 Scopus citations


Malignant liver tumors account for slightly >1% of all pediatric malignancies, with roughly 150 new cases of liver tumors diagnosed in the U.S. annually. The embryonal tumor, hepatoblastoma, accounts for two thirds of malignant liver tumors in children. Other liver malignancies in children include hepatocellular carcinoma, sarcomas, germ cell tumors, and rhabdoid tumors. Benign tumors of the liver in children include vascular tumors, hamartomas, and adenomas. There is an apparent increase in the incidence of hepatoblastoma with perinatal exposures and decreased premature infant mortality as postulated causes for this increased risk. The known causes and associations of liver tumors in children as well as the approaches to diagnosis and treatment of children are discussed in this review article.

Original languageEnglish (US)
Pages (from-to)812-820
Number of pages9
Issue number7
StatePublished - Jul 2008


  • Hepatoblastoma
  • Liver tumor
  • Pediatric cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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