Lithium Toxicity and PRES: A Novel Association

Ryan T. Fitzgerald, Caris T. Fitzgerald, Rohan S. Samant, Manoj Kumar, Raghu Ramakrishniah, Rudy Van Hemert, Edgardo J. Angtuaco

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We report two cases of posterior reversible encephalopathy syndrome (PRES) occurring in association with supra-therapeutic serum lithium levels. Although the neurologic manifestations of lithium toxicity are well known, this is, to our knowledge, the first report describing a link between lithium toxicity and PRES. We discuss the current understanding of the pathogenesis of PRES and suggest mechanisms by which lithium may play a role in its development.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalJournal of Neuroimaging
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes


  • Hypertensive encephalopathy
  • Lithium
  • Posterior reversible encephalopathy syndrome
  • Seizure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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