Abstract
Lithium carbonate has proven effective in controlling acute mania and in reducing the frequency and severity of recurrence of both mania and depression in bipolar patients.1-4 Several studies indicate that lithium is effective in certain unipolar depressions, but the results are inconsistent. Davis's recent review concluded that the magnitude of improvement associated with lithium was at least as great in unipolar as in bipolar depression.4 Mendels5 and Noyes et al.,6 using different approaches, noted that patients diagnosed as bipolar respond more frequently to lithium than do those diagnosed as unipolar. The purpose of this article is to present the problems in clarifying the kinds of depressions which do respond, and clinical guidelines for recognizing likely lithium responders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 227-231 |
| Number of pages | 5 |
| Journal | Comprehensive Psychiatry |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1978 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
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Lithium-responsive depression. / Bowden, Charles L.
In: Comprehensive Psychiatry, Vol. 19, No. 3, 1978, p. 227-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lithium-responsive depression
AU - Bowden, Charles L.
PY - 1978
Y1 - 1978
N2 - Lithium carbonate has proven effective in controlling acute mania and in reducing the frequency and severity of recurrence of both mania and depression in bipolar patients.1-4 Several studies indicate that lithium is effective in certain unipolar depressions, but the results are inconsistent. Davis's recent review concluded that the magnitude of improvement associated with lithium was at least as great in unipolar as in bipolar depression.4 Mendels5 and Noyes et al.,6 using different approaches, noted that patients diagnosed as bipolar respond more frequently to lithium than do those diagnosed as unipolar. The purpose of this article is to present the problems in clarifying the kinds of depressions which do respond, and clinical guidelines for recognizing likely lithium responders.
AB - Lithium carbonate has proven effective in controlling acute mania and in reducing the frequency and severity of recurrence of both mania and depression in bipolar patients.1-4 Several studies indicate that lithium is effective in certain unipolar depressions, but the results are inconsistent. Davis's recent review concluded that the magnitude of improvement associated with lithium was at least as great in unipolar as in bipolar depression.4 Mendels5 and Noyes et al.,6 using different approaches, noted that patients diagnosed as bipolar respond more frequently to lithium than do those diagnosed as unipolar. The purpose of this article is to present the problems in clarifying the kinds of depressions which do respond, and clinical guidelines for recognizing likely lithium responders.
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U2 - 10.1016/0010-440X(78)90041-X
DO - 10.1016/0010-440X(78)90041-X
M3 - Article
VL - 19
SP - 227
EP - 231
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
SN - 0010-440X
IS - 3
ER -