TY - JOUR
T1 - Lithium effect on renal glomerular functionin individuals with intellectual disability
AU - Janowsky, David S.
AU - Soares, Jair
AU - Hatch, John P.
AU - Zunta-Soares, Giovanna
AU - Hu, Qiaoyan
AU - Davis, John M.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2009/6
Y1 - 2009/6
N2 - OBJECTIVE: The current study evaluated the effects of chronic administration of lithium on renal functioning in an intellectually disabled population. METHODS: Fifty-seven lithium-treated individuals were compared with 24 behaviorally symptomatic controls using a retrospective chart review method. Serum creatinine levels and creatinine clearance activities were compared at baseline, at the time of peak creatinine levels, and at the end of the study in 2006. RESULTS: The mean length of lithium administration was 8.76 years (range, 1-23 years). Chronic lithium administration yielded a significant increase in peak serum creatinine levels and a decrease in the corresponding creatinine clearance activity. Of the subjects, 22.8% had peak creatinine levels of 1.5 mg or higher per 100 mL (a common threshold for renal insufficiency). This contrasted with 0% (none) for the symptomatic control subjects (P ≤ 0.008). In addition, 26.3% of the lithium-treated subjects had creatinine clearance activities less than 55 mL/min and 17.5% had less than 50 mL/min, both indicative of renal insufficiency, versus none of the symptomatic control subjects (P ≤ 0.004 and P ≤ 0.029, respectively). With lithium withdrawal, further deterioration of renal function did not occur in most cases, and many showed improvement, with decreases in serum creatinine levels and increases in creatinine clearance activity. CONCLUSIONS: Chronic administration of lithium led to clinically significant increases in serum creatinine levels and decreases in creatinine clearance in lithium-treated intellectually disabled individuals.
AB - OBJECTIVE: The current study evaluated the effects of chronic administration of lithium on renal functioning in an intellectually disabled population. METHODS: Fifty-seven lithium-treated individuals were compared with 24 behaviorally symptomatic controls using a retrospective chart review method. Serum creatinine levels and creatinine clearance activities were compared at baseline, at the time of peak creatinine levels, and at the end of the study in 2006. RESULTS: The mean length of lithium administration was 8.76 years (range, 1-23 years). Chronic lithium administration yielded a significant increase in peak serum creatinine levels and a decrease in the corresponding creatinine clearance activity. Of the subjects, 22.8% had peak creatinine levels of 1.5 mg or higher per 100 mL (a common threshold for renal insufficiency). This contrasted with 0% (none) for the symptomatic control subjects (P ≤ 0.008). In addition, 26.3% of the lithium-treated subjects had creatinine clearance activities less than 55 mL/min and 17.5% had less than 50 mL/min, both indicative of renal insufficiency, versus none of the symptomatic control subjects (P ≤ 0.004 and P ≤ 0.029, respectively). With lithium withdrawal, further deterioration of renal function did not occur in most cases, and many showed improvement, with decreases in serum creatinine levels and increases in creatinine clearance activity. CONCLUSIONS: Chronic administration of lithium led to clinically significant increases in serum creatinine levels and decreases in creatinine clearance in lithium-treated intellectually disabled individuals.
KW - Creatinine clearance
KW - Creatinine level
KW - Intellectual disability
KW - Kidney
KW - Lithium
KW - Mental retardation
KW - Renal insufficiency
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U2 - 10.1097/JCP.0b013e3181a5dcb7
DO - 10.1097/JCP.0b013e3181a5dcb7
M3 - Article
C2 - 19440087
AN - SCOPUS:67649243665
VL - 29
SP - 296
EP - 299
JO - Journal of Clinical Psychopharmacology
JF - Journal of Clinical Psychopharmacology
SN - 0271-0749
IS - 3
ER -