Lithium chloride SCN injection alters the orcadian rhythm of food intake

V. Reghunandanan, R. D. Badgaiyan, R. K. Marya, R. Reghunandanan, B. K. Maini

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Effect of lithium injections through chronically implanted cannulae into the bilateral suprachiasmatic nuclei (SCN) on the circadian rhythm of food intake was investigated in the rat. It was observed that the circadian rhythm was disrupted by injections of lithium at the beginning of the light as well as the dark phase of the LD cycle. In either case the percentage of the food consumed during the 12-hr light period increased while that during the dark period decreased without any significant change in the total daily intake. Disruptions in the circadian rhythm of food intake failed to show any dose-response relation. Injections of saline into the SCN or lithium into the nearby SCN area did not produce a disruption of the circadian rhythm of food intake.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalChronobiology international
Issue number2
StatePublished - 1989
Externally publishedYes


  • Circadian rhythm of food intake
  • Lithium
  • Suprachiasmatic nuclei
  • Vasopressin

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology


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