Abstract
Plasma levels and urinary excretion of lithium using lithium carbonate capsules from two manufacturers were correlated with the in vitro dissolution results. Tests indicated that the dissolution rates differed markedly for the two different capsules. It was also found that the absorption patterns of the capsules were different; one exhibited rapid initial absorption resulting in high peak levels, while the other showed a slower, more prolonged pattern. However, the extent of absorption of lithium was identical for the two preparations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 264-270 |
| Number of pages | 7 |
| Journal | Journal of Clinical Pharmacology |
| Volume | 13 |
| Issue number | 7 |
| State | Published - 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Lithium carbonate absorption in humans. / Sugita, E. T.; Stokes, J. W.; Frazer, Alan; Grof, P.; Mendels, J.; Goldstein, F. J.; Niebergall, P. J.
In: Journal of Clinical Pharmacology, Vol. 13, No. 7, 1973, p. 264-270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lithium carbonate absorption in humans
AU - Sugita, E. T.
AU - Stokes, J. W.
AU - Frazer, Alan
AU - Grof, P.
AU - Mendels, J.
AU - Goldstein, F. J.
AU - Niebergall, P. J.
PY - 1973
Y1 - 1973
N2 - Plasma levels and urinary excretion of lithium using lithium carbonate capsules from two manufacturers were correlated with the in vitro dissolution results. Tests indicated that the dissolution rates differed markedly for the two different capsules. It was also found that the absorption patterns of the capsules were different; one exhibited rapid initial absorption resulting in high peak levels, while the other showed a slower, more prolonged pattern. However, the extent of absorption of lithium was identical for the two preparations.
AB - Plasma levels and urinary excretion of lithium using lithium carbonate capsules from two manufacturers were correlated with the in vitro dissolution results. Tests indicated that the dissolution rates differed markedly for the two different capsules. It was also found that the absorption patterns of the capsules were different; one exhibited rapid initial absorption resulting in high peak levels, while the other showed a slower, more prolonged pattern. However, the extent of absorption of lithium was identical for the two preparations.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015827925&partnerID=8YFLogxK
M3 - Article
C2 - 4488996
AN - SCOPUS:0015827925
VL - 13
SP - 264
EP - 270
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
SN - 0091-2700
IS - 7
ER -