Lithium and impairment of renal concentrating ability

Alexander L. Miller; Charles L. Bowden; John Plewes

doi:10.1016/0165-0327(85)90089-8

Lithium and impairment of renal concentrating ability

Alexander L. Miller, Charles L. Bowden, John Plewes

Psychiatry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In 19 patients on lithium maintenance therapy, impairment of renal concentrating ability was found to correlate with daily lithium dose. The correlation between dose and impaired renal concentrating ability was strongest for patients on regular lithium preparations and not significant for patients on a slow release preparation. In 2 patients with severe polyuria, renal concentrating ability increased markedly with thiazide treatment. No relationship between lithium dosing parameters and other side effects was found. These results emphasize the importance of dose and type of preparation of lithium in the production of renal side effects.

Original language	English (US)
Pages (from-to)	115-119
Number of pages	5
Journal	Journal of Affective Disorders
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0165-0327(85)90089-8
State	Published - Sep 1985

Keywords

Lithium
Renal concentrating ability
Thiazide

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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AB - In 19 patients on lithium maintenance therapy, impairment of renal concentrating ability was found to correlate with daily lithium dose. The correlation between dose and impaired renal concentrating ability was strongest for patients on regular lithium preparations and not significant for patients on a slow release preparation. In 2 patients with severe polyuria, renal concentrating ability increased markedly with thiazide treatment. No relationship between lithium dosing parameters and other side effects was found. These results emphasize the importance of dose and type of preparation of lithium in the production of renal side effects.

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