Purpose: To present the preliminary results of β irradiation with use of liquid rhenium 188 (188Re)-filled balloon dilation in the treatment of refractory benign airway strictures. Materials and Methods: Ten sessions of β irradiation by using liquid 188Re-filled balloon dilation were prospectively performed in nine patients with refractory bronchial strictures between 2003 and 2006. Indications for treatment were dyspnea caused by repeat stricture or no response to previous treatment (ie, balloon dilation and/or temporary stent placement or laser therapy) in seven patients and dyspnea caused by exuberant granulation tissue formation at the distal end of the placed stent in two. To assess the treatment efficacy, the authors calculated and compared the mean intervals of interventional treatments before and after dilation with 188Re and mercaptoacetyltriglycine (MAG3)-filled balloons. Results: Liquid 188Re-filled balloon dilation was successfully performed in all nine patients, with no procedure-related complications. Immediately after the procedure, all patients showed resolution of their dyspnea. Five patients remained asymptomatic at 5-25-month follow-up. Four patients experienced dyspnea caused by recurrent stricture 1-10 months after dilation. The mean intervals between interventional treatments increased significantly from 3.1 months ± 2.1 before 188Re-MAG3-filled balloon dilation to 10.8 months ± 8.8 after 188Re-MAG3-filled balloon dilation in all nine patients (Wilcoxon signed rank test, P = .025). Conclusions: β irradiation with liquid 188Re-filled balloon dilation can be safely used for refractory benign airway strictures. A large study with longer follow-up is needed to draw a definite conclusion.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine