Lipoprotein(a) concentrations in Mexican Americans and non-hispanic whites: The San Antonio heart study

Steven M. Haffner, Katherine K. Gruber, Philip A. Morales, Helen P Hazuda, Rodolfo A. Valdez, Braxton D. Mitchell, Michael P. Stem

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

There is considerable evidence that lipoprotein(a) (Lp(a)) is a strong independent risk factor for coronary heart disease. Based on their risk factor profile, Mexican Americans have an increased risk of coronary heart disease, yet Mexican Americans have coronary heart disease mortality similar to or lower than that of non-Hispanic whites. The authors therefore attempted to determine whether Mexican Americans had decreased Lp(a) concentrations relative to non-Hispanic whites in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Lp(a) concentrations (mg/dl) were significantly lower in Mexican Americans (n = 316) than in non-Hispanic whites (n =242) (men: 10. 4 vs. 16. 3; women: 11. 5 vs. 16. 4). In addition, the proportion of persons with Lp(a) concentrations of ≥30 mg/dl (the threshold at which increased risk of coronary heart disease is believed to occur) was significantly higher in non-Hispanic whites than in Mexican Americans (18. 6% vs. 7. 6%; Mantel-Haenszel odds ratio (adjusted for sex) = 2. 79). Age, obesity, body fat distribution, cigarette smoking, alcohol consumption, and glucose and insulin concentrations were not significantly related to Lp(a) levels. Decreased Lp(a) concentrations may account in part for Mexican Americans' relative protection from coronary heart disease mortality. Am J Epidemiol 1992; 136: 1060-8

Original languageEnglish (US)
Pages (from-to)1060-1068
Number of pages9
JournalAmerican Journal of Epidemiology
Volume136
Issue number9
StatePublished - Nov 1 1992

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Lipoprotein(a)
Coronary Disease
Body Fat Distribution
Mortality
Alcohol Drinking
Cardiovascular Diseases
Obesity
Smoking
Odds Ratio
Insulin
Glucose
Population

Keywords

  • Coronary disease
  • Diabetes mellitus
  • Hispanic Americans
  • Lipoproteins

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Haffner, S. M., Gruber, K. K., Morales, P. A., Hazuda, H. P., Valdez, R. A., Mitchell, B. D., & Stem, M. P. (1992). Lipoprotein(a) concentrations in Mexican Americans and non-hispanic whites: The San Antonio heart study. American Journal of Epidemiology, 136(9), 1060-1068.

Lipoprotein(a) concentrations in Mexican Americans and non-hispanic whites : The San Antonio heart study. / Haffner, Steven M.; Gruber, Katherine K.; Morales, Philip A.; Hazuda, Helen P; Valdez, Rodolfo A.; Mitchell, Braxton D.; Stem, Michael P.

In: American Journal of Epidemiology, Vol. 136, No. 9, 01.11.1992, p. 1060-1068.

Research output: Contribution to journalArticle

Haffner, SM, Gruber, KK, Morales, PA, Hazuda, HP, Valdez, RA, Mitchell, BD & Stem, MP 1992, 'Lipoprotein(a) concentrations in Mexican Americans and non-hispanic whites: The San Antonio heart study', American Journal of Epidemiology, vol. 136, no. 9, pp. 1060-1068.
Haffner SM, Gruber KK, Morales PA, Hazuda HP, Valdez RA, Mitchell BD et al. Lipoprotein(a) concentrations in Mexican Americans and non-hispanic whites: The San Antonio heart study. American Journal of Epidemiology. 1992 Nov 1;136(9):1060-1068.
Haffner, Steven M. ; Gruber, Katherine K. ; Morales, Philip A. ; Hazuda, Helen P ; Valdez, Rodolfo A. ; Mitchell, Braxton D. ; Stem, Michael P. / Lipoprotein(a) concentrations in Mexican Americans and non-hispanic whites : The San Antonio heart study. In: American Journal of Epidemiology. 1992 ; Vol. 136, No. 9. pp. 1060-1068.
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