Lipopolysaccharide-induced suppression of antibody-directed cell-mediated cytotoxicity to chicken red blood cells

Thomas M. Folks, Charles J. Schlagel

    Research output: Contribution to journalArticle

    1 Scopus citations


    Prior treatment with commercially prepared and acetone-extracted lipopolysaccharide (LPS) was found to suppress the expression of antibody-directed, cell-mediated cytotoxicity (ADCC) to chicken red blood cells (CRBC) by spleen cells from C57/BL10, C3H, and BALB/c mice. The in vitro incubation with commercial LPS suppressed ADCC-CRBC activity of spleen cells from both C3H/HeJ and C3H/HeN mice. Only the C3H/HeN strain was suppressed when treated with purified LPS. ADCC-CRBC activity of neonatal spleen cells could be suppressed after a 3-hr in vivo incubation with LPS while adult spleen cells required a minimum of 15 hr preincubation.

    Original languageEnglish (US)
    Pages (from-to)97-103
    Number of pages7
    JournalCellular Immunology
    Issue number1
    StatePublished - Nov 15 1982


    ASJC Scopus subject areas

    • Immunology

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