Abstract
To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.
Original language | English (US) |
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Pages (from-to) | 151-157 |
Number of pages | 7 |
Journal | Journal of Alzheimer's Disease |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - 2012 |
Keywords
- Adiponectin
- Alzheimer's disease
- cholesterol
- leptin
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Clinical Psychology
- General Neuroscience