Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences

Kui Yang, Xianlin Han

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations

Abstract

Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based on analytical chemistry principles and technological tools, particularly mass spectrometry. Recently, techniques have greatly advanced and novel applications of lipidomics in the biomedical sciences have emerged. This review provides a timely update on these aspects. After briefly introducing the lipidomics discipline, we compare mass spectrometry-based techniques for analysis of lipids and summarize very recent applications of lipidomics in health and disease. Finally, we discuss the status of the field, future directions, and advantages and limitations of the field.

Original languageEnglish (US)
Pages (from-to)954-969
Number of pages16
JournalTrends in Biochemical Sciences
Volume41
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • biomedical science
  • lipid metabolism
  • lipidome
  • lipidomics
  • mass spectrometry
  • shotgun lipidomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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