TY - JOUR
T1 - Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains
AU - Wang, Chunyan
AU - Wang, Cheng
AU - Liu, Fang
AU - Rainosek, Shuo
AU - Patterson, Tucker A.
AU - Slikker, William
AU - Han, Xianlin
N1 - Funding Information:
This work was partly supported by National Institute of General Medical Sciences Grant No. R01 GM105724, the Methodist Hospital Foundation, UT Health SA intramural institutional research funds, and Mass Spectrometry Core Facility. Disclaimer: The information in these materials is not a formal dissemination of information by the FDA and does not represent agency position or policy.
Funding Information:
*E-mail: hanx@uthscsa.edu. ORCID Xianlin Han: 0000-0002-8615-2413 Funding This work was partly supported by National Institute of General Medical Sciences Grant No. R01 GM105724, the Methodist Hospital Foundation, UT Health SA intramural institutional research funds, and Mass Spectrometry Core Facility. Disclaimer: The information in these materials is not a formal dissemination of information by the FDA and does not represent agency position or policy. Notes The authors declare no competing financial interest. Biographies Chunyan Wang is a research scientist at the Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center at San Antonio, studying alterations in lipid metabolism and homeostasis under disease states by lipidomics. She has authored or coauthored over 30 peer-reviewed scientific articles and book chapters.
Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/9/17
Y1 - 2018/9/17
N2 - Numerous studies have demonstrated that treatment with high dose anesthetics for a prolonged duration induces brain injury in infants. However, whether anesthetic treatment leading to neurotoxicity is associated with alterations in lipid metabolism and homeostasis is still unclear. This review first outlines the lipidomics tools for analysis of lipid molecular species that can inform alterations in lipid species after anesthetic exposure. Then the available data indicating anesthetics cause changes in lipid profiles in the brain and serum of infant monkeys in preclinical studies are summarized, and the potential mechanisms leading to the altered lipid metabolism and their association with anesthetic-induced brain injury are also discussed. Finally, whether lipid changes identified in serum of infant monkeys can serve as indicators for the early detection of anesthetic-induced brain injury is described. We believe extensive studies on alterations in lipids after exposure to anesthetics will allow us to better understand anesthetic-induced neurotoxicity, unravel its underlying biochemical mechanisms, and develop powerful biomarkers for early detection/monitoring of the toxicity.
AB - Numerous studies have demonstrated that treatment with high dose anesthetics for a prolonged duration induces brain injury in infants. However, whether anesthetic treatment leading to neurotoxicity is associated with alterations in lipid metabolism and homeostasis is still unclear. This review first outlines the lipidomics tools for analysis of lipid molecular species that can inform alterations in lipid species after anesthetic exposure. Then the available data indicating anesthetics cause changes in lipid profiles in the brain and serum of infant monkeys in preclinical studies are summarized, and the potential mechanisms leading to the altered lipid metabolism and their association with anesthetic-induced brain injury are also discussed. Finally, whether lipid changes identified in serum of infant monkeys can serve as indicators for the early detection of anesthetic-induced brain injury is described. We believe extensive studies on alterations in lipids after exposure to anesthetics will allow us to better understand anesthetic-induced neurotoxicity, unravel its underlying biochemical mechanisms, and develop powerful biomarkers for early detection/monitoring of the toxicity.
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U2 - 10.1021/acs.chemrestox.8b00186
DO - 10.1021/acs.chemrestox.8b00186
M3 - Review article
C2 - 30132657
AN - SCOPUS:85053309189
SN - 0893-228X
VL - 31
SP - 825
EP - 835
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
IS - 9
ER -