Lipid profile of platelets and platelet-derived microparticles in ovarian cancer

Qianghua Hu, Miao Wang, Min Soon Cho, Chunyan Wang, Alpa M. Nick, Perumal Thiagarajan, Fleur M. Aung, Xianlin Han, Anil K. Sood, Vahid Afshar-Kharghan

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Ovarian cancer patients have a high risk of developing venous thrombosis. The membrane lipid bilayer of platelets and platelet-derived microparticles (PMP) provides a platform for assembly of coagulation proteins and generation of blood clots. Methods: We compared the lipid composition of platelets and PMPs in patients with ovarian cancer to those in healthy subjects. We used shotgun lipidomics to quantify 12 classes and 177 species of lipids. Results: We found a significant change in 2 classes of lipids in platelets and PMPs isolated from ovarian cancer patients: higher phosphatidylinositol and lower lyso-phosphatidylcholine. The level of 28 species of lipids was also significantly altered in the direction of an increase in the pro-coagulant and a reduction in the anticoagulant lipids. We found that cancer platelets expressed less lipid phosphate phosphatase 1 (LPP1), a key enzyme in phospholipid biosynthesis pathways, than normal platelets. The reduction in LPP1 might contribute to the changes in the lipid profile of cancer platelets. Conclusion: Our results support a procoagulant lipid profile of platelets in ovarian cancer patients that can play a role in the increased risk of venous thrombosis in these patients. General significance: As far as we are aware, our study is the first study on platelet lipidomics in ovarian cancer. The importance of our findings for the future studies are: 1) a similar change in lipid profile of platelets and PMP may be responsible for hypercoagulability in other cancers, and 2) plasma level of high-risk lipids for venous thrombosis may be useful biomarkers.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalBBA Clinical
StatePublished - Dec 1 2016
Externally publishedYes


  • Hypercoagulability
  • Lipid phosphate phosphatase 1
  • Lipidomics
  • Ovarian cancer
  • Platelet
  • Venous thrombosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Physiology (medical)


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