Lipid inhibitors of platelet-activating factor (PAF) in normal human plasma

Donna S. Woodard, Karen K. Ostrom, Linda M. McManus

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Endogenous, human plasma-derived lipids that inhibit the platelet stimulating activity of platelet-activating factor (PAF) have been identified. Chromatographic fractionation of neutral lipid PAF inhibitors revealed a majority of PAF inhibitory activity comigrating with cholesterol and a second peak localized with free fatty acids. Plasma phospholipids demonstrated theee distinct PAF inhibitory fractions in TLC regions corresponding to those of sphingomyelin, phosphatidylcholine and phosphatidylethanolamine. Three fractions (one neutral lipid and two phospholipid) specifically inhibited PAF-induced platelet activation. Thus, there are both specific and non-specific lipid inhibitors of PAF in normal human plasma. These plasma lipids may be important in the specific regulation of the diverse, potent biological activities of PAF in various physiological states.

Original languageEnglish (US)
Pages (from-to)11-28
Number of pages18
JournalJournal of Lipid Mediators and Cell Signalling
Volume12
Issue number1
DOIs
StatePublished - Jul 1995
Externally publishedYes

Keywords

  • 16:0-Alkyl-PAF
  • Neutral lipids
  • Phospholipids
  • Platelet-activating factor
  • Platelets
  • Thrombin

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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