Linkage of plasminogen (PLG) and apolipoprotein(a) (LPA) in baboons

John L. VandeBerg, Lowell Weitkamp, Candace M. Kammerer, P. Weill, Mary Jo Aivaliotis, David L. Rainwater

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    Four allelic forms of serum plasminogen (PLG) were detected in baboons (Papio hamadryas Linneaus 1758) by isoelectric focusing and were determined to be inherited as autosomal codominant traits. Linkage analysis of data from 179 progeny and their parents revealed that PLG is tightly linked (lod score = 30.20) to the gene encoding apolipoprotein(a) (LPA), as in humans. No recombinant individuals were identified. This is the first linkage detected between PLG and LPA in any species other than humans and is the first genetic linkage identified in a nonhuman primate species by family studies.

    Original languageEnglish (US)
    Pages (from-to)925-930
    Number of pages6
    JournalGenomics
    Volume11
    Issue number4
    DOIs
    StatePublished - Dec 1991

    ASJC Scopus subject areas

    • Genetics

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